Non-Hodgkin Lymphoma (NHL) in Children: an Epidemiologicial Analysis of NHL in Children in Albania during 2003-2012
Abstract
INTRODUCTION: Non-Hodgkin lymphoma (NHL) refers to a group of diverse tumors derived from cells of lymphocytic lineage. They occur as clonal proliferation of single cells at any stage of lymphocyte development. Sixty percent of all childhood lymphomas have been classified as non-Hodgkin‟s lymphoma, representing 8% of all childhood malignancies. In contrast to adult NHL, childhood NHL are typically high grade, they tent to present as advanced disease, yet with intensive multiagent chemotherapy, the outcome is favorable. THE AIM: The aim of the study was to analyze the demographical, epidemiological data of the Non-Hodgkin‟s lymphomas in the time period 2003-2012. METHODOLOGY: The study is a retrospective describing type, taken from January 2003 to December 2012 (a 10 year study). In this study, there were included data from cartels of the Pediatric Oncohematology the ward Hospital Center “Mother Teresa” in Tirana. In our country this service is unique, providing that our data can be considered with a national character. THE RESULT: In the study, there were involved a total of 53 patients. From that, 36 (67.9%) were male and 17 (32.1 %) female. The most affected age, was group age of 11-14 year olds and the group age with the lowest was 0-3 year olds. The most frequent clinical type was abdominal type 30/53 (56.6%) and the most frequent histological type was Burkitt‟s lymphoma 47.2 %. THE CONCLUSION: NHL, in our study is ranked in third place 8.6% after leukemia and brain tumors. In children, this disease is of a more aggressive type. This suggests a preventive campaign in the health education of the parents, the necessary information of the family doctor and the regional hospitals in order to have an earlier diagnosis. The future continues to be bright for increasing the long-term survival rate and decreasing the acute toxicity and long-term morbidity in children with both limited and advanced stage of the non-Hodgkin‟s lymphoma.
Keywords: NHL, lymphocyte, chemotherapy, UHC, group age, epidemiological data, histological type.
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