Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

Authors

  • Siham Lahsasni
  • Shaaban K. Mohamed
  • Mustafa R Albayati
  • Ahmed M. M. El-Saghier

Abstract

A Series Of Potential Biologically Active Compounds Have Been Synthesized Through The Derivatization of Carboxyl Group In Naproxen Core Structure Involving The Conversion The Naproxen To Its Methyl Ester Then To The
Acid Hydrazide. The Acid Hydrazide Of Naproxen Was Incorporated With Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline And Indole Containing Motifs. The Targeted Compounds Have Been Achieved In A Very Good Yield Under Conventional Heat And Irradiation Conditions. All Compounds Have Been Characterized By Ir, 1h-Nmr, 13c-Nmr And Mass Spectra.

Keywords: Naproxen; Anti-Inflammatory; Nsaid's.

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Published

2016-01-08

How to Cite

Lahsasni, S., Mohamed, S. K., Albayati, M. R., & El-Saghier, A. M. M. (2016). Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure. ANGLISTICUM. Journal of the Association-Institute for English Language and American Studies, 3. Retrieved from https://www.anglisticum.org.mk/index.php/IJLLIS/article/view/718

Issue

Section

Volume 3, Conference Proceedings, Special Issue, 2013